Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | TSHR | P16473 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1128076 | 0.75 | MAPT (0.62) | TDP1MAPTSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL29948882 | 0.75 | MAPT (0.62) | TDP1MAPTSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL12410039 | 0.74 | TDP1 (0.58) | TDP1MAPTSMN1; SMN2GAAHTT | |
| SCHEMBL28159262 | 0.74 | TDP1 (0.48) | TDP1MAPTSMN1; SMN2GAAHTT | |
| SCHEMBL27833133 | 0.70 | TDP1 (0.54) | TDP1MAPTGAAALDH1A1TSHR | |
| SCHEMBL31193292 | 0.70 | TDP1 (0.54) | TDP1MAPTGAAALDH1A1TSHR | |
| SCHEMBL2046631 | 0.69 | KDM4E (0.42) | TDP1MAPTSMN1; SMN2GAAHTT | |
| SCHEMBL7927969 | 0.68 | PDE10A (0.38) | TDP1MAPTSMN1; SMN2GAAHTT | |
| Phenazine SCHEMBL11666372 | 0.67 | MAPT (0.79) | TDP1MAPTSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL12991538 | 0.67 | TDP1 (0.55) | TDP1MAPTSMN1; SMN2GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321296-A1 | SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF | Bayer Schering Pharma Aktiengesellschaft (DE) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010020363-A1 | SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-02-25 | — | — | WO | disclosed |