Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HRH2 | P25021 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19966274 | 0.84 | KMT2A (0.45) | SMN1; SMN2NPC1RAB9ACYP2C19KMT2A | |
| SCHEMBL28636570 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9ACYP2C19KMT2A | |
| SCHEMBL92518 | 0.84 | L3MBTL1 (0.56) | SMN1; SMN2NPC1RAB9ACYP2C19KMT2A | |
| SCHEMBL23164394 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9ACYP2C19KMT2A | |
| SCHEMBL31663743 | 0.80 | HTR2C (0.52) | SMN1; SMN2NPC1RAB9ACYP2C19KMT2A | |
| SCHEMBL30485023 | 0.80 | HTR2C (0.52) | SMN1; SMN2NPC1RAB9ACYP2C19KMT2A | |
| SCHEMBL3074986 | 0.79 | MEN1 (0.52) | SMN1; SMN2NPC1RAB9ACYP2C19KMT2A | |
| SCHEMBL18123323 | 0.79 | MEN1 (0.50) | SMN1; SMN2NPC1RAB9ACYP2C19KMT2A | |
| SCHEMBL23821182 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9ACYP2C19KMT2A | |
| SCHEMBL1570844 | 0.78 | MEN1 (0.57) | SMN1; SMN2NPC1RAB9ACYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016157074-A1 | 6-MORPHOLINYL-2-PYRAZOLYL-9H-PURINE DERIVATIVES AND THEIR USE AS PI3K INHIBITORS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-10-06 | — | — | WO | disclosed |