Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 16/20 | 1.00 |
| ▸ | PTGER2 | P43116 | 8/20 | 1.00 |
| ▸ | PTGER3 | P43115 | 6/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | RARB | P10826 | 1/20 | 0.48 |
| ▸ | RARG | P13631 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | PTGIR | P43119 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19328437 | 1.00 | PTGER4 (1.00) | PTGER4PTGER2PTGER3KCNH2TSHR | |
| SCHEMBL15586916 | 1.00 | PTGER4 (1.00) | PTGER4PTGER2PTGER3KCNH2TSHR | |
| SCHEMBL18123935 | 1.00 | PTGER4 (1.00) | PTGER4PTGER2PTGER3KCNH2TSHR | |
| SCHEMBL16819470 | 1.00 | PTGER4 (1.00) | PTGER4PTGER2PTGER3KCNH2TSHR | |
| SCHEMBL15549258 | 1.00 | PTGER4 (1.00) | PTGER4PTGER2PTGER3KCNH2TSHR | |
| SCHEMBL15549261 | 1.00 | PTGER4 (1.00) | PTGER4PTGER2PTGER3KCNH2TSHR | |
| SCHEMBL15549260 | 1.00 | PTGER4 (1.00) | PTGER4PTGER2PTGER3KCNH2TSHR | |
| SCHEMBL16819283 | 0.89 | PTGER4 (0.80) | PTGER4PTGER2PTGER3KCNH2 | |
| SCHEMBL15549891 | 0.89 | PTGER4 (0.80) | PTGER4PTGER2PTGER3KCNH2 | |
| SCHEMBL22024698 | 0.89 | PTGER4 (0.80) | PTGER4PTGER2PTGER3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2875022-B1 | DIFLUOROLACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASE AND CONDITIONS | CAYMAN CHEMICAL CO INC (US) | 2016-10-12 | — | — | EP | claimed |
| EP-2874620-B1 | DIFLUOROLACTAM COMPOSITIONS FOR EP4-MEDIATED OSTEO RELATED DISEASES AND CONDITIONS | CAYMAN CHEMICAL CO INC (US) | 2016-10-12 | — | — | EP | claimed |