Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 5/20 | 0.33 |
| ▸ | ATM | Q13315 | 4/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18127406 | 0.84 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3HDAC2HDAC8 | |
| SCHEMBL18114398 | 0.84 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3HDAC2HDAC8 | |
| SCHEMBL18127123 | 0.78 | MEN1 (0.44) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18127118 | 0.78 | MEN1 (0.46) | SLC6A2SLC6A4SLC6A3HDAC2HDAC8 | |
| SCHEMBL18127394 | 0.76 | KMT2A (0.47) | HDAC2HDAC8HDAC6 | |
| SCHEMBL18127404 | 0.76 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3HDAC2HDAC8 | |
| SCHEMBL18127392 | 0.75 | GRM5 (0.42) | SLC6A2SLC6A4SLC6A3HCRTR1HCRTR2 | |
| SCHEMBL18127382 | 0.75 | HDAC8 (0.37) | SLC6A2SLC6A4SLC6A3HDAC2HDAC8 | |
| SCHEMBL18114460 | 0.75 | SIGMAR1 (0.48) | HDAC8HDAC6MMP1MMP9HCRTR1 | |
| SCHEMBL18127332 | 0.74 | ABCB1 (0.41) | SLC6A2SLC6A4SLC6A3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016160677-A1 | COMPOUNDS FOR THE TREATMENT OF ARENAVIRUS INFECTION | ARISAN THERAPEUTICS INC. (US) | 2016-10-06 | — | — | WO | disclosed |