Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18984688 | 0.97 | MAP4K4 (0.56) | MAP4K4ALDH1A1PARP1KCNH2HRH3 | |
| SCHEMBL375149 | 0.88 | MAP4K4 (0.58) | MAP4K4HRH3CARM1PRMT6 | |
| SCHEMBL18984649 | 0.86 | MAP4K4 (0.59) | MAP4K4CARM1PRMT6HCRTR1HCRTR2 | |
| SCHEMBL18129078 | 0.85 | MAP4K4 (0.56) | MAP4K4HRH3CARM1PRMT6HCRTR1 | |
| SCHEMBL18984676 | 0.83 | MAP4K4 (0.57) | MAP4K4ALDH1A1KCNH2KDM4EPKM | |
| SCHEMBL18129157 | 0.83 | MAP4K4 (0.58) | MAP4K4HRH3CARM1PRMT6HCRTR1 | |
| SCHEMBL8808220 | 0.81 | HRH3 (0.64) | ALDH1A1HRH3KDM4EPKMPOLB | |
| SCHEMBL23124608 | 0.79 | MEN1 (0.61) | HRH3POLBMEN1RAB9AKMT2A | |
| SCHEMBL8807848 | 0.77 | HRH3 (0.62) | MAP4K4ALDH1A1PARP1KCNH2HRH3 | |
| SCHEMBL18129023 | 0.76 | MAP4K4 (0.53) | MAP4K4PARP1HRH3PRMT6HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9592235-B2 | Aminoquinazoline and pyridopyrimidine derivatives | GENENTECH, INC. (US) | 2017-03-14 | — | — | US | disclosed |
| US-20160296525-A1 | AMINOQUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES | GENENTECH, INC. (US) | 2016-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160296525-A1 | AMINOQUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES | DPYD, FANCD2, RECQL | MAP4K4 700/4885ALDH1A1 534/4885PARP1 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.