Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 7/20 | 0.56 |
| ▸ | MAOA | P21397 | 4/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.52 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.49 |
| ▸ | SSTR3 | P32745 | 3/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL16799767 | 1.00 | KDM1A (0.56) | KDM1AMAOAGRIN2BFUCA1SSTR3 | |
| Bromide SCHEMBL17822691 | 1.00 | KDM1A (0.56) | KDM1AMAOAGRIN2BFUCA1SSTR3 | |
| Bromide SCHEMBL19876392 | 1.00 | KDM1A (0.56) | KDM1AMAOAGRIN2BFUCA1SSTR3 | |
| Bromide SCHEMBL18106675 | 1.00 | KDM1A (0.56) | KDM1AMAOAGRIN2BFUCA1SSTR3 | |
| Bromide SCHEMBL17822672 | 1.00 | KDM1A (0.56) | KDM1AMAOAGRIN2BFUCA1SSTR3 | |
| Bromide SCHEMBL17822680 | 1.00 | KDM1A (0.56) | KDM1AMAOAGRIN2BFUCA1SSTR3 | |
| SCHEMBL2198525 | 0.98 | KDM1A (0.58) | KDM1AMAOAGRIN2BFUCA1SSTR3 | |
| SCHEMBL2197651 | 0.98 | KDM1A (0.58) | KDM1AMAOAGRIN2BFUCA1SSTR3 | |
| SCHEMBL2798417 | 0.98 | KDM1A (0.58) | KDM1AMAOAGRIN2BFUCA1SSTR3 | |
| SCHEMBL491107 | 0.98 | KDM1A (0.58) | KDM1AMAOAGRIN2BFUCA1SSTR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025853-A1 | SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES | FMC CORPORATION | 2024-01-25 | — | — | US | disclosed |
| US-11787765-B2 | Substituted cyclic amides and their use as herbicides | FMC CORPORATION (US) | 2023-10-17 | — | — | US | disclosed |
| US-20230270111-A1 | PYRROLIDINONES HERBICIDES | E.I. DU PONT DE NEMOURS AND COMPANY | 2023-08-31 | — | — | US | disclosed |
| US-11634421-B2 | Aryl substituted bicyclic compounds as herbicides | FMC CORPORATION (US) | 2023-04-25 | — | — | US | disclosed |
| EP-3663282-B1 | PYRROLIDINONE HERBICIDES | FMC CORP (US) | 2022-05-18 | — | — | EP | disclosed |
| US-20220127229-A1 | SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES | FMC CORPORATION | 2022-04-28 | — | — | US | disclosed |
| EP-3280709-B1 | SUBSTITUTED CYCLIC AMIDES AS HERBICIDES | FMC CORP (US) | 2021-05-26 | — | — | EP | disclosed |
| EP-3303287-B1 | SUBSTITUTED CYCLIC AMIDES AS HERBICIDES | FMC CORP (US) | 2020-12-16 | — | — | EP | disclosed |
| EP-3663282-A1 | PYRROLIDINONE HERBICIDES | FMC Corporation (US) | 2020-06-10 | — | — | EP | disclosed |
| EP-3650430-A1 | INTERMEDIATES AND PROCESSES FOR THE SYNTHESIS OF HERBICIDES | FMC Corporation (US) | 2020-05-13 | — | — | EP | disclosed |
| EP-3077374-B1 | PYRROLIDINONES AS HERBICIDES | FMC CORP (US) | 2020-02-05 | — | — | EP | disclosed |
| US-20200031836-A1 | ARYL SUBSTITUTED BICYCLIC COMPOUNDS AS HERBICIDES | FMC CORP (US) | 2020-01-30 | — | — | US | disclosed |
| EP-3294743-B1 | ARYL SUBSTITUTED BICYCLIC COMPOUNDS AS HERBICIDES | FMC CORP (US) | 2019-08-21 | — | — | EP | disclosed |
| US-10294202-B2 | Pyrrolidinones as herbicides | FMC CORPORATION (US) | 2019-05-21 | — | — | US | disclosed |
| EP-3303321-A1 | SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES | E. I. du Pont de Nemours and Company (US) | 2018-04-11 | — | — | EP | disclosed |
| EP-3294743-A1 | ARYL SUBSTITUTED BICYCLIC COMPOUNDS AS HERBICIDES | E. I. du Pont de Nemours and Company (US) | 2018-03-21 | — | — | EP | disclosed |
| WO-2016196593-A1 | SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES | E I DU PONT DE NEMOURS AND COMPANY (US) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016182780-A1 | ARYL SUBSTITUTED BICYCLIC COMPOUNDS AS HERBICIDES | E I DU PONT DE NEMOURS AND COMPANY (US) | 2016-11-17 | — | — | WO | disclosed |
| US-20160297756-A1 | PYRROLIDINONES AS HERBICIDES | FMC CORPORATION | 2016-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297756-A1 | PYRROLIDINONES AS HERBICIDES | DDT, ARG1, PRMT1 | ACHE 269/4885KDM1A 310/4885MAOA 1369/4885 |
| US-11787765-B2 | Substituted cyclic amides and their use as herbicides | NIT2, ARG1, CNPY2 | ACHE 78/4885KDM1A 796/4885MAOA 1121/4885 |
| US-10294202-B2 | Pyrrolidinones as herbicides | DDT, ARG1, PRMT1 | ACHE 269/4885KDM1A 310/4885MAOA 1369/4885 |
| US-20240025853-A1 | SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES | NIT2, ARG1, CNPY2 | ACHE 78/4885KDM1A 801/4885MAOA 1104/4885 |
| US-20230270111-A1 | PYRROLIDINONES HERBICIDES | DDT, ARG1, CYP1B1 | ACHE 232/4885KDM1A 546/4885MAOA 1167/4885 |
| US-20200031836-A1 | ARYL SUBSTITUTED BICYCLIC COMPOUNDS AS HERBICIDES | CYP1B1, CYP1A1, CBR3 | ACHE 318/4885KDM1A 459/4885MAOA 407/4885 |
| US-11634421-B2 | Aryl substituted bicyclic compounds as herbicides | CYP1B1, CYP1A1, CBR3 | ACHE 318/4885KDM1A 459/4885MAOA 407/4885 |
| US-20220127229-A1 | SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES | NIT2, ARG1, CNPY2 | ACHE 78/4885KDM1A 796/4885MAOA 1121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.