Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | PPP1R15A | O75807 | 1/20 | 0.42 |
| ▸ | MELK | Q14680 | 1/20 | 0.42 |
| ▸ | PPP1R15B | Q5SWA1 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MPI | P34949 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18131614 | 1.00 | LMNA (0.46) | LMNASMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL16993764 | 0.88 | LMNA (0.58) | LMNASMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL31105625 | 0.88 | LMNA (0.58) | LMNASMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL16993763 | 0.88 | LMNA (0.58) | LMNASMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL5703097 | 0.86 | LMNA (0.57) | LMNASMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL5703099 | 0.86 | LMNA (0.57) | LMNASMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL30913080 | 0.84 | NPC1 (0.55) | LMNASMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL5460775 | 0.84 | NPC1 (0.55) | LMNASMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL5460773 | 0.84 | NPC1 (0.55) | LMNASMN1; SMN2ALDH1A1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL11686106 | 0.83 | GRIN2D (0.54) | LMNASMN1; SMN2ALDH1A1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11337941-B2 | Inhibitors and their uses | UNITED KINGDOM RESEARCH AND INNOVATION (GB) | 2022-05-24 | — | — | US | disclosed |
| US-11331286-B2 | Inhibitors and their uses | UNITED KINGDOM RESEARCH AND INNOVATION (GB) | 2022-05-17 | — | — | US | disclosed |
| US-11154519-B2 | Inhibitors and their uses | UNITED KINGDOM RESEARCH AND INNOVATION (GB) | 2021-10-26 | — | — | US | disclosed |
| CN-107709291-B | Inhibitors and uses thereof | 医疗研究局 | 2021-03-12 | — | — | CN | disclosed |
| US-20200297668-A1 | INHIBITORS AND THEIR USES | MEDICAL RESEARCH COUNCIL (GB) | 2020-09-24 | — | — | US | disclosed |
| US-20200197337-A1 | INHIBITORS AND THEIR USES | MEDICAL RESEARCH COUNCIL (GB) | 2020-06-25 | — | — | US | disclosed |
| US-20180111896-A1 | INHIBITORS AND THEIR USES | MEDICAL RESEARCH COUNCIL (GB) | 2018-04-26 | — | — | US | disclosed |
| EP-3280405-A1 | INHIBITORS AND THEIR USES | Medical Research Council (GB) | 2018-02-14 | — | — | EP | disclosed |
| WO-2016162689-A1 | INHIBITORS AND THEIR USES | MEDICAL RESEARCH COUNCIL (GB) | 2016-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180111896-A1 | INHIBITORS AND THEIR USES | PPP1R1B, PPP5C, PPP1R15A | LMNA 1988/4885SMN1; SMN2 627/4885ALDH1A1 2580/4885 |
| US-11154519-B2 | Inhibitors and their uses | PPP1R1B, PPP5C, PPP1R15A | LMNA 1988/4885SMN1; SMN2 627/4885ALDH1A1 2580/4885 |
| US-11331286-B2 | Inhibitors and their uses | PPP1R1B, PPP5C, PPP1R15A | LMNA 1988/4885SMN1; SMN2 627/4885ALDH1A1 2580/4885 |
| US-20200297668-A1 | INHIBITORS AND THEIR USES | PPP1R1B, PPP5C, PPP1R15A | LMNA 1988/4885SMN1; SMN2 627/4885ALDH1A1 2580/4885 |
| US-11337941-B2 | Inhibitors and their uses | PPP1R1B, PPP5C, PPP1R15A | LMNA 1988/4885SMN1; SMN2 627/4885ALDH1A1 2580/4885 |
| US-20200197337-A1 | INHIBITORS AND THEIR USES | PPP1R1B, PPP5C, PPP1R15A | LMNA 1988/4885SMN1; SMN2 627/4885ALDH1A1 2580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.