Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 14/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21386671 | 0.91 | FGFR4 (0.64) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21756495 | 0.80 | FGFR4 (0.66) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131721 | 0.78 | FGFR4 (0.85) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131753 | 0.77 | FGFR4 (0.43) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131754 | 0.77 | FGFR4 (0.43) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21386622 | 0.76 | FGFR4 (0.65) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21386606 | 0.74 | FGFR4 (0.73) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131707 | 0.74 | FGFR4 (0.56) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131718 | 0.74 | FGFR4 (0.41) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131810 | 0.74 | FGFR1 (0.70) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |