Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 19/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.58 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18131722 | 0.84 | FGFR4 (1.00) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21386622 | 0.83 | FGFR4 (0.65) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21386671 | 0.82 | FGFR4 (0.64) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL20093934 | 0.79 | FGFR4 (0.89) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131734 | 0.77 | FGFR4 (0.87) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131721 | 0.76 | FGFR4 (0.85) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131746 | 0.76 | FGFR4 (0.84) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL20093908 | 0.75 | FGFR4 (0.51) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131831 | 0.75 | FGFR4 (0.84) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131702 | 0.74 | FGFR4 (0.55) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543227-B1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2020-12-30 | — | — | EP | disclosed |
| EP-3543227-A1 | FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | Guangdong Zhongsheng Pharmaceutical Co., Ltd (CN) | 2019-09-25 | — | — | EP | disclosed |