Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27267807 | 0.80 | POLB (0.53) | KDM4EL3MBTL1ALDH1A1TDP1NPSR1 | |
| SCHEMBL29918922 | 0.79 | L3MBTL1 (0.45) | KDM4EASPHKDM8SSTR4L3MBTL1 | |
| SCHEMBL2067513 | 0.79 | L3MBTL1 (0.45) | KDM4EASPHKDM8SSTR4L3MBTL1 | |
| SCHEMBL28200557 | 0.75 | ATR (0.41) | KDM4EASPHKDM8SSTR4ALDH1A1 | |
| SCHEMBL30990531 | 0.74 | KDM4E (0.63) | KDM4EASPHKDM8L3MBTL1ALDH1A1 | |
| SCHEMBL15060252 | 0.74 | KDM4E (0.63) | KDM4EASPHKDM8L3MBTL1ALDH1A1 | |
| SCHEMBL21561868 | 0.73 | KDM4E (0.43) | KDM4EASPHKDM8SSTR4ALDH1A1 | |
| SCHEMBL2065683 | 0.73 | KDM4E (0.61) | KDM4EASPHKDM8L3MBTL1ALDH1A1 | |
| SCHEMBL30605221 | 0.72 | KDM4E (0.37) | KDM4EASPHKDM8SSTR4ALDH1A1 | |
| SCHEMBL29122703 | 0.72 | L3MBTL1 (0.37) | L3MBTL1ALDH1A1GAAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3280715-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | Beigene, Ltd. (KY) | 2018-02-14 | — | — | EP | disclosed |
| WO-2016161960-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE, LTD. (KY) | 2016-10-13 | — | — | WO | disclosed |