Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | ADH5 | P11766 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL242208 | 0.91 | MAPT (0.59) | MAPTKDM4EMEN1KMT2ATDP1 | |
| SCHEMBL3260075 | 0.89 | MAPT (0.47) | MAPTKDM4EMEN1KMT2ATDP1 | |
| SCHEMBL18124134 | 0.86 | MAPT (0.53) | MAPTKDM4EMEN1KMT2ATDP1 | |
| SCHEMBL1903922 | 0.85 | MAPT (0.48) | MAPTKDM4EMEN1KMT2ATDP1 | |
| SCHEMBL242209 | 0.83 | ADH5 (0.67) | MAPTKDM4EMEN1KMT2ATDP1 | |
| SCHEMBL18124133 | 0.82 | MAPT (0.57) | MAPTKDM4EMEN1KMT2ATDP1 | |
| SCHEMBL1973775 | 0.81 | PTGS1 (0.57) | MAPTKDM4EMEN1KMT2ATDP1 | |
| SCHEMBL1826897 | 0.81 | ADH5 (0.54) | MAPTKDM4EMEN1KMT2ATDP1 | |
| SCHEMBL244757 | 0.78 | MAPT (0.69) | MAPTKDM4EMEN1KMT2ATDP1 | |
| SCHEMBL1837441 | 0.78 | MAPT (0.52) | MAPTKDM4EMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318006-B1 | NOVEL PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE AS THERAPEUTIC AGENTS | NIVALIS THERAPEUTICS INC (US) | 2016-10-12 | — | — | EP | disclosed |