Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 16/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14986949 | 0.92 | GLS (1.00) | GLSALDH1A1CA2 | |
| SCHEMBL15727744 | 0.87 | GLS (0.89) | GLSALDH1A1CA2 | |
| SCHEMBL14987001 | 0.87 | GLS (0.89) | GLSALDH1A1CA2 | |
| SCHEMBL14987262 | 0.83 | GLS (0.82) | GLSALDH1A1CA2 | |
| SCHEMBL16384868 | 0.81 | GLS (0.78) | GLSALDH1A1CA2 | |
| SCHEMBL14987443 | 0.80 | GLS (1.00) | GLS | |
| SCHEMBL15042405 | 0.77 | GLS (0.88) | GLSALDH1A1CA2 | |
| SCHEMBL14987258 | 0.77 | GLS (0.70) | GLSALDH1A1CA2 | |
| SCHEMBL21484237 | 0.76 | GLS (0.68) | GLSALDH1A1CA2 | |
| SCHEMBL14986996 | 0.75 | GLS (0.90) | GLSALDH1A1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164401-A1 | TREATMENT OF LUNG CANCER WITH INHIBITORS OF GLUTAMINASE | CALITHERA BIOSCIENCES, INC. (US) | 2016-10-13 | — | — | WO | disclosed |