Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 14/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16305175 | 0.93 | GLS (0.65) | GLSLMNAMAPTGAAHTT | |
| SCHEMBL14987621 | 0.93 | GLS (0.65) | GLSLMNAMAPTGAAHTT | |
| SCHEMBL14987547 | 0.91 | GLS (0.75) | GLSLMNAMAPTGAAHTT | |
| SCHEMBL19920328 | 0.91 | GLS (0.75) | GLSLMNAMAPTGAAHTT | |
| SCHEMBL17087063 | 0.85 | GLS (0.58) | GLSLMNAMAPT | |
| SCHEMBL15042339 | 0.83 | GLS (0.80) | GLSLMNAMAPTCTSSCTSK | |
| SCHEMBL16305174 | 0.83 | GLS (0.80) | GLSLMNAMAPTCTSSCTSK | |
| SCHEMBL15727776 | 0.80 | GLS (0.76) | GLS | |
| SCHEMBL21369057 | 0.78 | GLS (0.71) | GLSLMNAMAPT | |
| SCHEMBL14987541 | 0.77 | GLS (1.00) | GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782570-B1 | HETEROCYCLIC INHIBITORS OF GLUTAMINASE | CALITHERA BIOSCIENCES INC (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2016164401-A1 | TREATMENT OF LUNG CANCER WITH INHIBITORS OF GLUTAMINASE | CALITHERA BIOSCIENCES, INC. (US) | 2016-10-13 | — | — | WO | disclosed |