Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18137604 | 1.00 | IDO1 (0.65) | IDO1TDO2 | |
| SCHEMBL18137664 | 1.00 | IDO1 (0.65) | IDO1TDO2 | |
| SCHEMBL20001932 | 1.00 | IDO1 (0.65) | IDO1TDO2 | |
| SCHEMBL19951121 | 1.00 | IDO1 (0.65) | IDO1TDO2 | |
| SCHEMBL18137633 | 0.98 | IDO1 (0.63) | IDO1TDO2 | |
| SCHEMBL18137665 | 0.95 | IDO1 (0.59) | IDO1TDO2 | |
| SCHEMBL18137379 | 0.92 | IDO1 (0.55) | IDO1TDO2 | |
| SCHEMBL18137609 | 0.86 | IDO1 (0.49) | IDO1TDO2 | |
| SCHEMBL18137663 | 0.86 | IDO1 (0.49) | IDO1TDO2 | |
| Hydrochloric Acid SCHEMBL19951133 | 0.85 | IDO1 (0.48) | IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3280715-B1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE LTD (KY) | 2020-11-25 | — | — | EP | disclosed |
| EP-3280715-B1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE LTD (KY) | 2020-11-25 | — | — | EP | disclosed |
| US-10647714-B2 | 5 or 8-substituted imidazo[1,5-a]pyridines as indoleamine and/or tryptophane 2,3-dioxygenases | BEIGENE, LTD. (KY) | 2020-05-12 | — | — | US | disclosed |
| US-10647714-B2 | 5 or 8-substituted imidazo[1,5-a]pyridines as indoleamine and/or tryptophane 2,3-dioxygenases | BEIGENE, LTD. (KY) | 2020-05-12 | — | — | US | disclosed |
| US-20190284184-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1,5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2,3-DIOXYGENASES | BEONE MEDICINES I GMBH (CH) | 2019-09-19 | — | — | US | disclosed |
| US-20190284184-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1,5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2,3-DIOXYGENASES | BEONE MEDICINES I GMBH (CH) | 2019-09-19 | — | — | US | disclosed |
| US-10280163-B2 | 5 or 8-substituted imidazo[1, 5-a] pyridines as indoleamine and/or tryptophane 2, 3-dioxygenases | BEIGENE, LTD. (KY) | 2019-05-07 | — | — | US | disclosed |
| US-10280163-B2 | 5 or 8-substituted imidazo[1, 5-a] pyridines as indoleamine and/or tryptophane 2, 3-dioxygenases | BEIGENE, LTD. (KY) | 2019-05-07 | — | — | US | disclosed |
| US-20180072716-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEONE MEDICINES I GMBH (CH) | 2018-03-15 | — | — | US | disclosed |
| US-20180072716-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEONE MEDICINES I GMBH (CH) | 2018-03-15 | — | — | US | disclosed |
| US-20180072716-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEONE MEDICINES I GMBH (CH) | 2018-03-15 | — | — | US | disclosed |
| WO-2016161960-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE, LTD. (KY) | 2016-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10280163-B2 | 5 or 8-substituted imidazo[1, 5-a] pyridines as indoleamine and/or tryptophane 2, 3-dioxygenases | IDO1, TPH1, IDO2 | IDO1 1/4885TDO2 5/4885 |
| US-10647714-B2 | 5 or 8-substituted imidazo[1,5-a]pyridines as indoleamine and/or tryptophane 2,3-dioxygenases | IDO1, TPH1, IDO2 | IDO1 1/4885TDO2 5/4885 |
| US-20190284184-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1,5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2,3-DIOXYGENASES | IDO1, TPH1, IDO2 | IDO1 1/4885TDO2 5/4885 |
| US-20180072716-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | IDO1, TPH1, IDO2 | IDO1 1/4885TDO2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.