SCHEMBL1813784

SCHEMBL1813784

Nc1ncccc1-c1cn(Cc2ccc(OCc3ccc(Cl)cc3)cc2)nn1

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 7/20 0.52
PTGS2 P35354 1/20 0.42
CCNK O75909 1/20 0.42
CDK12 Q9NYV4 1/20 0.42
MAOB P27338 3/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
KDR P35968 1/20 0.41
EPHB4 P54760 1/20 0.41
TEK Q02763 1/20 0.41
DHFR P00374 1/20 0.41
TTBK1 Q5TCY1 1/20 0.41
TTBK2 Q6IQ55 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
NR1I3 Q14994 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1734185 0.92 CYP19A1 (0.51) CYP19A1CCNKCDK12KDREPHB4
SCHEMBL1816497 0.91 TEK (0.43) CYP19A1CCNKCDK12NPC1RAB9A
SCHEMBL1808527 0.91 NPC1 (0.53) CYP19A1PTGS2CCNKCDK12NPC1
SCHEMBL1806051 0.90 EPHB4 (0.45) CYP19A1PTGS2CCNKCDK12MAOB
SCHEMBL1805789 0.90 MAOB (0.49) CYP19A1CCNKCDK12MAOBKDR
SCHEMBL1804661 0.89 NPC1 (0.52) CYP19A1CCNKCDK12NPC1RAB9A
SCHEMBL1808185 0.88 CYP19A1 (0.44) CYP19A1CCNKCDK12KDREPHB4
SCHEMBL1808810 0.88 TEK (0.45) CYP19A1CCNKCDK12MAOBKDR
SCHEMBL1804004 0.88 HSP90AA1 (0.55) CYP19A1CCNKCDK12NPC1RAB9A
SCHEMBL1813493 0.86 MAOB (0.45) CYP19A1CCNKCDK12MAOBKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011051198-A2 PYRIDINE DERIVATIVES AS AGRICULTURAL PESTICIDES BAYER CROPSCIENCE AG (DE) 2011-05-05 WO claimed
WO-2011051198-A2 PYRIDINE DERIVATIVES AS AGRICULTURAL PESTICIDES BAYER CROPSCIENCE AG (DE) 2011-05-05 WO disclosed