SCHEMBL1814208

SCHEMBL1814208

COc1ccc(CCNC(=O)c2c(C)cccc2C)cc1Cl

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.55
ALDH1A1 P00352 2/20 0.55
TAAR1 Q96RJ0 1/20 0.54
NAMPT P43490 2/20 0.52
MAPT P10636 3/20 0.52
CNR1 P21554 3/20 0.52
CNR2 P34972 3/20 0.52
LMNA P02545 3/20 0.51
CA1 P00915 1/20 0.51
CA2 P00918 1/20 0.51
MEN1 O00255 1/20 0.51
POLB P06746 1/20 0.51
KMT2A Q03164 1/20 0.51
DNMT3A Q9Y6K1 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1815403 0.87 NPC1 (0.55) GAAALDH1A1NAMPTMAPTCNR1
SCHEMBL1811698 0.81 NPC1 (0.63) GAAALDH1A1MAPTLMNAPOLB
SCHEMBL3028083 0.78 HDAC1 (0.56) GAAALDH1A1MAPTLMNA
SCHEMBL17205863 0.78 CA1 (0.62) LMNACA1CA2MEN1KMT2A
SCHEMBL16135570 0.77 GAA (0.66) GAAALDH1A1LMNAMEN1KMT2A
SCHEMBL6022541 0.76 CA1 (0.57) GAALMNACA1CA2MEN1
SCHEMBL17695175 0.76 ALDH1A1 (0.64) ALDH1A1LMNAMEN1POLBKMT2A
SCHEMBL3233643 0.76 TAAR1 (0.51) GAAALDH1A1TAAR1MAPTMEN1
SCHEMBL3018090 0.75 GAA (0.61) GAAMAPTLMNACA1CA2
SCHEMBL13210682 0.75 GAA (0.61) GAAALDH1A1MAPTCNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110237678-A1 N-(1-METHYL-2PHENYLETHYL)BENZAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2011-09-29 US claimed
US-20090156682-A1 N-(1-Methyl-2Phenylethyl)Benzamide Derivatives BAYER INTELLECTUAL PROPERTY GMBH (DE) 2009-06-18 US claimed
EP-1960350-A1 NEW N-(1-METHYL-2PHENYLETHYL)BENZAMIDE DERIVATIVES BAYER CROPSCIENCE SA (FR) 2008-08-27 EP claimed
WO-2007060162-A1 NEW N-(1-METHYL-2PHENYLETHYL)BENZAMIDE DERIVATIVES BAYER CROPSCIENCE SA (FR) 2007-05-31 WO claimed
US-8314269-B2 N-(1-methyl-2phenylethyl)benzamide derivatives BAYER CROPSCIENCE AG (DE) 2012-11-20 US disclosed
US-20110237678-A1 N-(1-METHYL-2PHENYLETHYL)BENZAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2011-09-29 US disclosed
US-7951973-B2 N-(1-methyl-2Phenylethyl)benzamide derivatives BAYER CROPSCIENCE AG (DE) 2011-05-31 US disclosed
US-20090156682-A1 N-(1-Methyl-2Phenylethyl)Benzamide Derivatives BAYER INTELLECTUAL PROPERTY GMBH (DE) 2009-06-18 US disclosed
EP-1960350-A1 NEW N-(1-METHYL-2PHENYLETHYL)BENZAMIDE DERIVATIVES BAYER CROPSCIENCE SA (FR) 2008-08-27 EP disclosed
WO-2007060162-A1 NEW N-(1-METHYL-2PHENYLETHYL)BENZAMIDE DERIVATIVES BAYER CROPSCIENCE SA (FR) 2007-05-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090156682-A1 N-(1-Methyl-2Phenylethyl)Benzamide Derivatives CYP51A1, CYP1A2, CYP1A1 GAA 59/4885ALDH1A1 393/4885TAAR1 3254/4885
US-20110237678-A1 N-(1-METHYL-2PHENYLETHYL)BENZAMIDE DERIVATIVES CYP51A1, CYP1A2, CYP1A1 GAA 61/4885ALDH1A1 429/4885TAAR1 3271/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.