Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | CNKSR1 | Q969H4 | 8/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18148049 | 1.00 | LMNA (0.37) | LMNASMN1; SMN2KEAP1NFE2L2PLA2G1B | |
| SCHEMBL18148042 | 0.88 | CNKSR1 (0.48) | LMNACNKSR1KDM4EALDH1A1HPGD | |
| SCHEMBL18148038 | 0.83 | CNKSR1 (0.51) | SMN1; SMN2CNKSR1AKT1ALDH1A1 | |
| SCHEMBL18148035 | 0.83 | CNKSR1 (0.51) | SMN1; SMN2CNKSR1AKT1ALDH1A1 | |
| SCHEMBL18148029 | 0.76 | CNKSR1 (0.39) | CNKSR1ALDH1A1HPGDPOLBTDP1 | |
| SCHEMBL18148208 | 0.75 | CNKSR1 (0.62) | SMN1; SMN2CNKSR1AKT1ALDH1A1 | |
| SCHEMBL18148044 | 0.69 | LMNA (0.37) | LMNASMN1; SMN2KEAP1NFE2L2CNKSR1 | |
| SCHEMBL18148041 | 0.69 | LMNA (0.37) | LMNASMN1; SMN2KEAP1NFE2L2CNKSR1 | |
| SCHEMBL18148050 | 0.62 | CNKSR1 (0.51) | CNKSR1AKT1HPGD | |
| SCHEMBL18148033 | 0.60 | HDAC1 (0.36) | LMNASMN1; SMN2CNKSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227356-B2 | Compounds, compositions and methods for inhibiting CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| US-20160304533-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227356-B2 | Compounds, compositions and methods for inhibiting CNKSR1 | CNKSR1, CAMKK1, CNR1 | LMNA 1703/4885SMN1; SMN2 3032/4885KEAP1 1253/4885 |
| US-20160304533-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR INHIBITING CNKSR1 | CNKSR1, CAMKK1, CNR1 | LMNA 1703/4885SMN1; SMN2 3032/4885KEAP1 1253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.