Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 20/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30627835 | 0.74 | TACR3 (0.43) | TACR3KCNH2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL31694710 | 0.71 | TACR3 (0.56) | TACR3KCNH2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL17994148 | 0.71 | TACR3 (0.56) | TACR3KCNH2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL22414337 | 0.70 | TACR3 (0.45) | TACR3KCNH2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL16116207 | 0.69 | TACR3 (1.00) | TACR3KCNH2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL16115665 | 0.69 | TACR3 (1.00) | TACR3KCNH2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL16291363 | 0.69 | TACR3 (0.56) | TACR3KCNH2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL16136294 | 0.69 | TACR3 (1.00) | TACR3KCNH2CYP2C9CYP2C19TACR1 | |
| SCHEMBL16114849 | 0.67 | TACR3 (1.00) | TACR3KCNH2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL29941223 | 0.67 | TACR3 (0.36) | TACR3KCNH2CYP2C9CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969738-B2 | N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders | OGEDA SA (BE) | 2018-05-15 | — | — | US | claimed |
| US-20160304521-A1 | NOVEL N-ACYL-(3-SUBSTITUTED)-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERS | OGEDA SA (BE) | 2016-10-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160304521-A1 | NOVEL N-ACYL-(3-SUBSTITUTED)-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERS | KCNK3, GPR3, ACKR3 | TACR3 21/4885KCNH2 77/4885CYP2C9 2678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.