Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 15/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.46 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.46 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.45 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3906718 | 0.82 | SLC22A12 (0.50) | SLC22A12BRD4CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL3913044 | 0.81 | BRD4 (0.46) | SLC22A12BRD4 | |
| SCHEMBL1814225 | 0.81 | PTGDR2 (0.46) | BRD4 | |
| SCHEMBL5615200 | 0.79 | GSPT1 (0.47) | BRD4CYP2C9GSPT1DDB1CRBN | |
| SCHEMBL1809299 | 0.75 | PTGDR2 (0.47) | BRD4 | |
| SCHEMBL1821354 | 0.73 | BRD4 (0.59) | BRD4PTPN2PTPN1PTPN5 | |
| SCHEMBL3769130 | 0.72 | SLC22A12 (0.70) | SLC22A12CYP2C9SLC22A6SLC22A8SLC22A11 | |
| SCHEMBL6659042 | 0.70 | SLC22A12 (0.51) | SLC22A12CYP2C9SLC22A6SLC22A8SLC22A11 | |
| SCHEMBL1461802 | 0.70 | SLC22A12 (0.55) | SLC22A12BRD4CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL1812383 | 0.69 | SLC22A12 (0.48) | SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4682207-B2 | — | — | 2011-05-11 | — | — | JP | claimed |
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | claimed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | claimed |