Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CPS1 | P31327 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27970559 | 1.00 | CYP1A2 (0.40) | CYP1A2TDP1TSHRLMNAALOX15 | |
| SCHEMBL21354258 | 0.88 | TSHR (0.41) | TSHRLMNAALOX15HSD17B10L3MBTL1 | |
| SCHEMBL17061936 | 0.88 | TSHR (0.41) | TSHRLMNAALOX15HSD17B10L3MBTL1 | |
| SCHEMBL17061934 | 0.88 | TSHR (0.41) | TSHRLMNAALOX15HSD17B10L3MBTL1 | |
| SCHEMBL10941145 | 0.88 | CYP1A2 (0.43) | CYP1A2TDP1TSHRLMNAALOX15 | |
| SCHEMBL7995036 | 0.86 | TSHR (0.41) | TSHRLMNAALOX15HSD17B10L3MBTL1 | |
| SCHEMBL4150920 | 0.86 | TSHR (0.41) | TSHRLMNAALOX15HSD17B10L3MBTL1 | |
| SCHEMBL28742997 | 0.82 | TSHR (0.39) | TSHRLMNAALOX15HSD17B10L3MBTL1 | |
| SCHEMBL28915964 | 0.82 | TSHR (0.39) | TSHRLMNAALOX15HSD17B10L3MBTL1 | |
| SCHEMBL28915023 | 0.82 | TSHR (0.39) | TSHRLMNAALOX15HSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294726-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | AbbVie Inc. (US) | 2018-03-21 | — | — | EP | disclosed |
| WO-2016168633-A1 | INDAZOLONES AS MODULATORS OF TNF SIGNALING | ABBVIE INC. (US) | 2016-10-20 | — | — | WO | disclosed |
| CN-103814027-A | Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and their use as C5A receptor modulators | NOVARTIS AG | 2014-05-21 | — | — | CN | disclosed |