Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.35 |
| ▸ | NQO2 | P16083 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CDC25A | P30304 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12034737 | 0.79 | PARP1 (0.41) | CYP19A1NQO2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL31700720 | 0.74 | KDM4E (0.35) | KDM4EALDH1A1SMN1; SMN2PARP1L3MBTL1 | |
| SCHEMBL14848190 | 0.72 | NAPRT (0.48) | KDM4EALDH1A1SMN1; SMN2L3MBTL1POLB | |
| SCHEMBL27298899 | 0.72 | JAK2 (0.39) | KDM4EALDH1A1SMN1; SMN2PARP1HPGD | |
| SCHEMBL791101 | 0.72 | — | — | |
| SCHEMBL7413081 | 0.71 | PDPK1 (0.39) | PARP1L3MBTL1TUBB4ATUBBTUBA3C | |
| SCHEMBL14829330 | 0.70 | ALDH1A1 (0.52) | KDM4EALDH1A1L3MBTL1POLBHPGD | |
| SCHEMBL1053740 | 0.70 | POLB (0.54) | CYP19A1NQO2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL18257252 | 0.70 | PDE3B (0.40) | CYP19A1NQO2KDM4EALDH1A1PARP1 | |
| SCHEMBL3174185 | 0.69 | SMN1; SMN2 (0.40) | KDM4EALDH1A1SMN1; SMN2HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283077-A2 | BROMODOMAIN INHIBITOR | Celgene Quanticel Research, Inc. (US) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016168682-A2 | BROMODOMAIN INHIBITOR | CELGENE QUANTICEL RESEARCH, INC. (US) | 2016-10-20 | — | — | WO | disclosed |