Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.35 |
| ▸ | ALKBH3 | Q96Q83 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL855883 | 0.70 | NPSR1 (0.49) | SMN1; SMN2ARHPGDALDH1A1LMNA | |
| SCHEMBL12496103 | 0.67 | SMN1; SMN2 (0.59) | SMN1; SMN2ADCY10HPGDALDH1A1LMNA | |
| SCHEMBL27851698 | 0.66 | NPSR1 (0.45) | SMN1; SMN2ARHPGDALDH1A1LMNA | |
| SCHEMBL856305 | 0.65 | NPSR1 (0.44) | SMN1; SMN2ARHPGDALDH1A1LMNA | |
| SCHEMBL856234 | 0.64 | SMN1; SMN2 (0.53) | SMN1; SMN2ARHPGDALDH1A1LMNA | |
| SCHEMBL16016391 | 0.63 | ALDH1A1 (0.49) | SMN1; SMN2MDM2ALKBH3HPGDALDH1A1 | |
| SCHEMBL28195339 | 0.61 | SMN1; SMN2 (0.46) | SMN1; SMN2MDM2ALDH1A1LMNAMAPT | |
| SCHEMBL654288 | 0.61 | NPC1 (0.41) | SMN1; SMN2ARHPGDLMNAMAPT | |
| SCHEMBL12495499 | 0.61 | KMT2A (0.44) | SMN1; SMN2HPGDALDH1A1LMNAGAA | |
| SCHEMBL12495498 | 0.61 | KMT2A (0.44) | SMN1; SMN2HPGDALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283077-A2 | BROMODOMAIN INHIBITOR | Celgene Quanticel Research, Inc. (US) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016168682-A2 | BROMODOMAIN INHIBITOR | CELGENE QUANTICEL RESEARCH, INC. (US) | 2016-10-20 | — | — | WO | disclosed |