Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 11/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.34 |
| ▸ | CCNC | P24863 | 2/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.33 |
| ▸ | CLK1 | P49759 | 2/20 | 0.33 |
| ▸ | CLK2 | P49760 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.33 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.33 |
| ▸ | CSNK1G3 | Q9Y6M4 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18153218 | 1.00 | TNF (0.39) | TNFRIPK1CCNCCDK8CLK1 | |
| SCHEMBL18151489 | 0.86 | ATM (0.41) | TNF | |
| SCHEMBL29987453 | 0.85 | TNF (0.41) | TNFRIPK1CCNCCDK8CLK1 | |
| SCHEMBL18151336 | 0.85 | TNF (0.39) | TNFRIPK1CCNCCDK8CLK1 | |
| SCHEMBL18151456 | 0.85 | TNF (0.41) | TNFRIPK1CCNCCDK8CLK1 | |
| SCHEMBL18153251 | 0.85 | TNF (0.37) | TNFRIPK1CCNCCDK8P2RX7 | |
| SCHEMBL18151234 | 0.83 | TNF (0.41) | TNF | |
| SCHEMBL18151013 | 0.83 | TNF (0.41) | TNF | |
| SCHEMBL18150909 | 0.83 | TNF (0.41) | TNF | |
| SCHEMBL18150993 | 0.83 | CYP11B1 (0.41) | TNFRIPK1CCNCCDK8CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288939-A1 | TRICYCLIC MODULATORS OF TNF SIGNALING | AbbVie Inc. (US) | 2018-03-07 | — | — | EP | disclosed |
| WO-2016168641-A1 | TRICYCLIC MODULATORS OF TNF SIGNALING | ABBVIE INC. (US) | 2016-10-20 | — | — | WO | disclosed |