Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 8/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18150959 | 0.89 | TNF (0.38) | TNFCCNCCDK8HDAC6HDAC8 | |
| SCHEMBL18151156 | 0.87 | TNF (0.38) | TNFCCNCCDK8HDAC6HDAC8 | |
| SCHEMBL18150817 | 0.87 | TNF (0.38) | TNFCCNCCDK8HDAC6HDAC8 | |
| SCHEMBL18150881 | 0.86 | TNF (0.37) | TNFCCNCCDK8HDAC6HDAC8 | |
| SCHEMBL18150804 | 0.86 | FTO (0.37) | TNFCCNCCDK8HDAC6HDAC8 | |
| SCHEMBL18150897 | 0.86 | TNF (0.40) | TNFCCNCCDK8HDAC6HDAC8 | |
| SCHEMBL29795081 | 0.86 | TNF (0.40) | TNFCCNCCDK8HDAC6HDAC8 | |
| SCHEMBL18151244 | 0.85 | PIK3CA (0.41) | TNFCCNCCDK8PIK3CAMTOR | |
| SCHEMBL29795074 | 0.85 | PIK3CA (0.41) | TNFCCNCCDK8PIK3CAMTOR | |
| SCHEMBL18153218 | 0.85 | TNF (0.39) | TNFCCNCCDK8P2RX7RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288939-A1 | TRICYCLIC MODULATORS OF TNF SIGNALING | AbbVie Inc. (US) | 2018-03-07 | — | — | EP | disclosed |
| WO-2016168641-A1 | TRICYCLIC MODULATORS OF TNF SIGNALING | ABBVIE INC. (US) | 2016-10-20 | — | — | WO | disclosed |