Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 4/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | GAK | O14976 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18150738 | 0.91 | AOC3 (0.43) | TNFAOC3KCNH2MTORPIK3CA | |
| SCHEMBL18150795 | 0.91 | AOC3 (0.43) | TNFAOC3KCNH2MTORPIK3CA | |
| SCHEMBL18151375 | 0.91 | AOC3 (0.43) | TNFAOC3KCNH2MTORPIK3CA | |
| SCHEMBL31292071 | 0.89 | TNF (0.39) | TNFAOC3HDAC6HDAC8HDAC1 | |
| SCHEMBL18151071 | 0.88 | AOC3 (0.36) | TNFAOC3KCNH2MTORBRD4 | |
| SCHEMBL18153272 | 0.88 | AOC3 (0.36) | TNFAOC3KCNH2MTORBRD4 | |
| SCHEMBL18150982 | 0.87 | TNF (0.34) | TNFAOC3HDAC6HDAC8HDAC1 | |
| SCHEMBL18150682 | 0.87 | TNF (0.38) | TNFAOC3HDAC6HDAC8HDAC1 | |
| SCHEMBL18150888 | 0.87 | AOC3 (0.40) | TNFAOC3KCNH2MTORPIK3CA | |
| SCHEMBL18153231 | 0.86 | TNF (0.37) | TNFAOC3HDAC6HDAC8HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288939-A1 | TRICYCLIC MODULATORS OF TNF SIGNALING | AbbVie Inc. (US) | 2018-03-07 | — | — | EP | claimed |
| WO-2016168641-A1 | TRICYCLIC MODULATORS OF TNF SIGNALING | ABBVIE INC. (US) | 2016-10-20 | — | — | WO | claimed |
| EP-3288939-A1 | TRICYCLIC MODULATORS OF TNF SIGNALING | AbbVie Inc. (US) | 2018-03-07 | — | — | EP | disclosed |
| WO-2016168641-A1 | TRICYCLIC MODULATORS OF TNF SIGNALING | ABBVIE INC. (US) | 2016-10-20 | — | — | WO | disclosed |