Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18151601 | 1.00 | DRD2 (0.34) | DRD2GRM2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18159769 | 0.87 | TNF (0.42) | KMT2ATNFGAAHTR2BTSHR | |
| SCHEMBL18151454 | 0.87 | TNF (0.42) | KMT2ATNFGAAHTR2BTSHR | |
| SCHEMBL18151018 | 0.84 | EPAS1 (0.34) | MAPTTP53 | |
| SCHEMBL18151433 | 0.84 | TNF (0.44) | DRD2GRM2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18151734 | 0.84 | PDE2A (0.37) | SMN1; SMN2MAPTTP53NPM1ALK | |
| SCHEMBL18150334 | 0.84 | PDE2A (0.37) | SMN1; SMN2MAPTTP53NPM1ALK | |
| SCHEMBL18153327 | 0.82 | TNF (0.39) | DRD2MEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL18150892 | 0.82 | TNF (0.39) | DRD2MEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL18150861 | 0.81 | DRD3 (0.33) | GRM2TNFGAAHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288939-A1 | TRICYCLIC MODULATORS OF TNF SIGNALING | AbbVie Inc. (US) | 2018-03-07 | — | — | EP | disclosed |
| WO-2016168641-A1 | TRICYCLIC MODULATORS OF TNF SIGNALING | ABBVIE INC. (US) | 2016-10-20 | — | — | WO | disclosed |