Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 17/20 | 0.73 |
| ▸ | FGFR4 | P22455 | 9/20 | 0.73 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.73 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19732375 | 0.92 | FGFR1 (0.72) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL20025867 | 0.90 | FGFR1 (0.80) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL17740810 | 0.90 | FGFR1 (0.73) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL18153622 | 0.89 | FGFR1 (0.57) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL18162423 | 0.89 | FGFR1 (0.83) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL18153619 | 0.87 | FGFR1 (0.55) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL29412748 | 0.85 | FGFR1 (1.00) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL30274661 | 0.85 | FGFR1 (1.00) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL16659467 | 0.85 | FGFR1 (1.00) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL30070526 | 0.84 | FGFR1 (0.99) | FGFR1FGFR4FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107660200-B | Crystalline FGFR4 inhibitor compounds and uses thereof | 卫材R&D管理有限公司 | 2022-01-11 | — | — | CN | disclosed |
| EP-3283465-A1 | CRYSTALLINE FGFR4 INHIBITOR COMPOUND AND USES THEREOF | Eisai R&D Management Co., Ltd. (JP) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016168331-A1 | CRYSTALLINE FGFR4 INHIBITOR COMPOUND AND USES THEREOF | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-10-20 | — | — | WO | disclosed |