Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 17/20 | 0.57 |
| ▸ | FGFR4 | P22455 | 10/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.57 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.57 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | INSR | P06213 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | FYN | P06241 | 2/20 | 0.54 |
| ▸ | YES1 | P07947 | 2/20 | 0.54 |
| ▸ | LYN | P07948 | 2/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | MET | P08581 | 2/20 | 0.54 |
| ▸ | ROS1 | P08922 | 2/20 | 0.54 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | BRAF | P15056 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.54 |
| ▸ | FLT1 | P17948 | 2/20 | 0.54 |
| ▸ | TYK2 | P29597 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18153619 | 0.90 | FGFR1 (0.55) | FGFR1FGFR4FGFR2FGFR3JAK2 | |
| SCHEMBL18153620 | 0.89 | FGFR1 (0.73) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL16659545 | 0.86 | FGFR1 (0.52) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL17740814 | 0.85 | FGFR4 (0.49) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL22157668 | 0.82 | FGFR1 (0.48) | FGFR1FGFR4FGFR2FGFR3JAK2 | |
| SCHEMBL16654071 | 0.82 | FGFR1 (0.79) | FGFR1FGFR4FGFR2FGFR3JAK2 | |
| SCHEMBL16659402 | 0.82 | FGFR1 (0.54) | FGFR1FGFR4FGFR2FGFR3JAK2 | |
| SCHEMBL19732375 | 0.81 | FGFR1 (0.72) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL17740810 | 0.80 | FGFR1 (0.73) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL17728850 | 0.80 | FGFR1 (0.46) | FGFR1FGFR4FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107660200-B | Crystalline FGFR4 inhibitor compounds and uses thereof | 卫材R&D管理有限公司 | 2022-01-11 | — | — | CN | disclosed |
| EP-3283465-A1 | CRYSTALLINE FGFR4 INHIBITOR COMPOUND AND USES THEREOF | Eisai R&D Management Co., Ltd. (JP) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016168331-A1 | CRYSTALLINE FGFR4 INHIBITOR COMPOUND AND USES THEREOF | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-10-20 | — | — | WO | disclosed |