Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26683906 | 0.87 | SIGMAR1 (0.47) | MCL1SIGMAR1 | |
| SCHEMBL18154570 | 0.81 | BACE1 (0.43) | SIGMAR1NPC1RAB9ALMNAMAPT | |
| SCHEMBL20022865 | 0.77 | HTR2A (0.65) | MCL1SIGMAR1HTR2AHTR2CMAPT | |
| SCHEMBL26683837 | 0.76 | SIGMAR1 (0.46) | SIGMAR1 | |
| SCHEMBL5229747 | 0.76 | HTR2A (0.39) | MCL1HTR2AHTR2CNPC1RAB9A | |
| SCHEMBL20022863 | 0.74 | HTR2A (0.40) | MCL1SIGMAR1HTR2AHTR2C | |
| SCHEMBL6712407 | 0.74 | SIGMAR1 (0.40) | SIGMAR1HTR2AHTR2CNPC1RAB9A | |
| SCHEMBL31573855 | 0.73 | HTR2A (0.42) | MCL1SIGMAR1HTR2AHTR2CHRH3 | |
| SCHEMBL21981723 | 0.71 | MCL1 (0.39) | MCL1SIGMAR1NPC1RAB9ALMNA | |
| SCHEMBL23725782 | 0.70 | HTR2A (0.50) | SIGMAR1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286193-A1 | INDOLE DERIVATIVES | Richter Gedeon Nyrt. (HU) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016166684-A1 | INDOLE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2016-10-20 | — | — | WO | disclosed |