SCHEMBL18154569

SCHEMBL18154569

CC(C)N1CCc2c(Cl)c3cc(-n4ccc(OCc5ccccc5)cc4=O)ccc3n2CC1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 20/20 0.66
CYP3A4 P08684 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30701113 0.85 MCHR1 (0.58) MCHR1
SCHEMBL18154582 0.85 MCHR1 (0.58) MCHR1
Hydrochloric Acid SCHEMBL21981717 0.84 MCHR1 (0.59) MCHR1CYP3A4
SCHEMBL18154520 0.82 MCHR1 (0.67) MCHR1CYP3A4
Maleic Acid SCHEMBL21981725 0.82 MCHR1 (0.52) MCHR1
SCHEMBL12927535 0.80 MCHR1 (1.00) MCHR1CYP3A4
Hydrochloric Acid SCHEMBL1005367 0.79 MCHR1 (0.98) MCHR1CYP3A4
SCHEMBL21981726 0.78 MCHR1 (0.57) MCHR1
Maleic Acid SCHEMBL18154587 0.78 MCHR1 (0.61) MCHR1CYP3A4
Fumaric Acid SCHEMBL18154588 0.78 MCHR1 (0.61) MCHR1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023242810-A1 MCHR1 ANTAGONISTS FOR THE TREATMENT OF PRADER-WILLI SYNDROME RICHTER GEDEON NYRT. (HU) 2023-12-21 WO claimed
EP-3286193-B1 INDOLE DERIVATIVES RICHTER GEDEON NYRT (HU) 2020-05-27 EP claimed
WO-2023242810-A1 MCHR1 ANTAGONISTS FOR THE TREATMENT OF PRADER-WILLI SYNDROME RICHTER GEDEON NYRT. (HU) 2023-12-21 WO disclosed
EP-3286193-A1 INDOLE DERIVATIVES Richter Gedeon Nyrt. (HU) 2018-02-28 EP disclosed
WO-2016166684-A1 INDOLE DERIVATIVES RICHTER GEDEON NYRT. (HU) 2016-10-20 WO disclosed