SCHEMBL18154520

SCHEMBL18154520

CC(C)N1CCc2cc3cc(-n4ccc(OCc5ccccc5)cc4=O)ccc3n2CC1

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 20/20 0.67
CYP3A4 P08684 3/20 0.51
KCNH2 Q12809 5/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Maleic Acid SCHEMBL18154587 0.94 MCHR1 (0.61) MCHR1CYP3A4KCNH2
Fumaric Acid SCHEMBL18154588 0.94 MCHR1 (0.61) MCHR1CYP3A4KCNH2
SCHEMBL21981715 0.91 MCHR1 (0.56) MCHR1KCNH2
SCHEMBL31573838 0.91 MCHR1 (0.56) MCHR1KCNH2
SCHEMBL21981718 0.91 MCHR1 (0.56) MCHR1KCNH2
SCHEMBL18154549 0.88 MCHR1 (0.61) MCHR1CYP3A4KCNH2
SCHEMBL21981712 0.88 MCHR1 (0.53) MCHR1CYP3A4KCNH2
SCHEMBL30700892 0.88 MCHR1 (0.53) MCHR1CYP3A4KCNH2
SCHEMBL31573843 0.85 MCHR1 (0.51) MCHR1CYP3A4KCNH2
SCHEMBL18154571 0.84 MCHR1 (0.51) MCHR1CYP3A4KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023242810-A1 MCHR1 ANTAGONISTS FOR THE TREATMENT OF PRADER-WILLI SYNDROME RICHTER GEDEON NYRT. (HU) 2023-12-21 WO claimed
EP-3286193-B1 INDOLE DERIVATIVES RICHTER GEDEON NYRT (HU) 2020-05-27 EP claimed
WO-2025094152-A1 18F AND11C RADIOLABELED MCHR1 PET LIGANDS RICHTER GEDEON NYRT. (HU) 2025-05-08 WO disclosed
WO-2023242810-A1 MCHR1 ANTAGONISTS FOR THE TREATMENT OF PRADER-WILLI SYNDROME RICHTER GEDEON NYRT. (HU) 2023-12-21 WO disclosed
EP-3286193-A1 INDOLE DERIVATIVES Richter Gedeon Nyrt. (HU) 2018-02-28 EP disclosed
WO-2016166684-A1 INDOLE DERIVATIVES RICHTER GEDEON NYRT. (HU) 2016-10-20 WO disclosed