Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | UBE2N | P61088 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 3/20 | 0.37 |
| ▸ | CASP4 | P49662 | 1/20 | 0.37 |
| ▸ | CASP5 | P51878 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18154724 | 0.77 | GUSB (0.46) | ALDH1A1HPGDKDM4EAPAF1POLB | |
| SCHEMBL4476048 | 0.72 | HRH1 (0.43) | ALDH1A1HPGDKDM4EAPAF1POLB | |
| SCHEMBL18154763 | 0.72 | SMN1; SMN2 (0.59) | ALDH1A1HPGDKDM4EAPAF1POLB | |
| SCHEMBL9488077 | 0.71 | HRH1 (0.59) | ALDH1A1HPGDKDM4EAPAF1POLB | |
| Hydrochloric Acid SCHEMBL8582704 | 0.70 | HRH1 (0.57) | ALDH1A1HPGDKDM4EAPAF1POLB | |
| SCHEMBL6664557 | 0.67 | HRH1 (0.44) | ALDH1A1HPGDKDM4EAPAF1POLB | |
| SCHEMBL1229731 | 0.67 | HRH1 (0.85) | ALDH1A1HPGDKDM4EPOLBHRH1 | |
| SCHEMBL8962532 | 0.66 | HRH1 (0.61) | ALDH1A1HPGDKDM4EAPAF1POLB | |
| SCHEMBL6027662 | 0.66 | HRH1 (0.61) | ALDH1A1HPGDKDM4EAPAF1POLB | |
| Hydrochloric Acid SCHEMBL18153315 | 0.66 | HTR2A (0.46) | ALDH1A1HPGDKDM4EAPAF1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283482-A1 | PLK4 INHIBITORS | Ludwig Institute for Cancer Research Ltd (CH) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016166604-A1 | PLK4 INHIBITORS | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) | 2016-10-20 | — | — | WO | disclosed |