Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP4 | P49662 | 1/20 | 0.49 |
| ▸ | CASP5 | P51878 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6700853 | 0.79 | DHFR (0.58) | HRH1HRH4ALDH1A1DHFR | |
| Water SCHEMBL11002492 | 0.78 | DHFR (0.56) | HRH1HRH4ALDH1A1DHFR | |
| SCHEMBL778188 | 0.76 | SMN1; SMN2 (1.00) | SMN1; SMN2USP2TDP1HRH1CASP1 | |
| SCHEMBL18154762 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2USP2TDP1HRH1CASP1 | |
| SCHEMBL8542091 | 0.74 | HRH1 (1.00) | SMN1; SMN2USP2TDP1HRH1CASP1 | |
| SCHEMBL4476048 | 0.73 | HRH1 (0.43) | SMN1; SMN2USP2TDP1HRH1CASP1 | |
| Acetic Acid SCHEMBL10653160 | 0.73 | DHFR (0.55) | CASP1HRH4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL9488077 | 0.73 | HRH1 (0.59) | SMN1; SMN2USP2TDP1HRH1CASP1 | |
| SCHEMBL8608360 | 0.72 | ALDH1A1 (0.53) | SMN1; SMN2USP2TDP1HRH1HRH4 | |
| SCHEMBL18154725 | 0.72 | ALDH1A1 (0.45) | SMN1; SMN2USP2TDP1HRH1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283482-A1 | PLK4 INHIBITORS | Ludwig Institute for Cancer Research Ltd (CH) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016166604-A1 | PLK4 INHIBITORS | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) | 2016-10-20 | — | — | WO | disclosed |