Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 11/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 13/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730823 | 0.81 | NUDT1 (0.68) | JAK1NUDT1JAK2JAK3EGLN2 | |
| SCHEMBL20338418 | 0.78 | JAK1 (0.75) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL28485655 | 0.74 | AHR (0.47) | NUDT1 | |
| SCHEMBL19658699 | 0.73 | GRM2 (0.44) | JAK1NUDT1 | |
| SCHEMBL218914 | 0.72 | JAK2 (0.78) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL19658700 | 0.72 | NUDT1 (0.38) | JAK1NUDT1JAK2JAK3EGLN2 | |
| SCHEMBL21797154 | 0.72 | JAK2 (0.63) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL22439076 | 0.71 | KDM4E (0.43) | NUDT1 | |
| SCHEMBL29079138 | 0.71 | NUDT1 (0.61) | JAK1NUDT1JAK2JAK3EGLN2 | |
| SCHEMBL31429929 | 0.71 | JAK2 (0.56) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113677676-A | Novel method for preparing non-gautinib and intermediate thereof | 联合化学实验室有限公司 | 2021-11-19 | — | — | CN | disclosed |
| EP-3842432-A1 | NOVEL SALTS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | Galapagos N.V. (BE) | 2021-06-30 | — | — | EP | disclosed |
| EP-3283114-A1 | METHODS FOR THE TREATMENT OF CARDIOVASCULAR DISORDERS | Galapagos NV (BE) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016165952-A1 | METHODS FOR THE TREATMENT OF CARDIOVASCULAR DISORDERS | GALAPAGOS NV (BE) | 2016-10-20 | — | — | WO | disclosed |