Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.47 |
| ▸ | KDR | P35968 | 7/20 | 0.47 |
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TOP1 | P11387 | 2/20 | 0.42 |
| ▸ | TOP2A | P11388 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18155038 | 0.87 | AURKA (0.52) | BRD4TGFB2FGFR1PDGFRBKDR | |
| SCHEMBL18164007 | 0.85 | TGFB2 (0.52) | TGFB2FGFR1PDGFRBKDRMET | |
| SCHEMBL18163900 | 0.83 | TGFB2 (0.59) | BRD4TGFB2FGFR1PDGFRBKDR | |
| SCHEMBL18163968 | 0.83 | TGFB2 (0.44) | TGFB2FGFR1PDGFRBKDRMET | |
| SCHEMBL18164074 | 0.82 | MET (0.46) | BRD4TGFB2FGFR1PDGFRBKDR | |
| SCHEMBL2680623 | 0.82 | FYN (0.48) | BRD4FGFR1PDGFRBKDRMET | |
| SCHEMBL18164072 | 0.82 | TGFB2 (0.71) | BRD4TGFB2FGFR1PDGFRBKDR | |
| SCHEMBL18155117 | 0.80 | TGFB2 (0.53) | BRD4TGFB2FGFR1PDGFRBKDR | |
| SCHEMBL18155091 | 0.79 | FGFR1 (0.50) | TGFB2FGFR1PDGFRBKDRMET | |
| SCHEMBL18155044 | 0.79 | TGFB2 (0.67) | BRD4TGFB2FGFR1PDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283475-B1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-10-16 | — | — | EP | claimed |
| EP-3283475-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | Merck Patent GmbH (DE) | 2018-02-21 | — | — | EP | claimed |
| WO-2016165808-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | WO | claimed |
| US-10179777-B2 | 3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one derivatives | MERCK PATENT GMBH (DE) | 2019-01-15 | — | — | US | disclosed |
| US-20180099947-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-04-12 | — | — | US | disclosed |
| EP-3283475-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | Merck Patent GmbH (DE) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016165808-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | WO | disclosed |
| WO-2016165808-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10179777-B2 | 3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one derivatives | ALK, ABL2, ACVR1 | BRD4 1969/4885TGFB2 267/4885FGFR1 26/4885 |
| US-20180099947-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | ALK, ABL2, ACVR1 | BRD4 1969/4885TGFB2 267/4885FGFR1 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.