Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11555850 | 0.89 | MAPT (0.61) | MAPTKDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL259406 | 0.79 | MAPT (0.69) | MAPTKDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL22455919 | 0.78 | MAPT (0.60) | MAPTKDM4EL3MBTL1LMNAMAPK1 | |
| SCHEMBL10740552 | 0.78 | MAPT (0.52) | MAPTKDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL2711990 | 0.77 | MAPT (0.77) | MAPTKDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL7800482 | 0.77 | GAA (0.72) | MAPTKDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL18157848 | 0.77 | MAPT (0.69) | MAPTKDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL27883230 | 0.77 | MAPT (0.64) | MAPTKDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL10760236 | 0.77 | MAPT (0.61) | MAPTKDM4EL3MBTL1LMNATDP1 | |
| SCHEMBL18110699 | 0.77 | MAPT (0.53) | MAPTKDM4EL3MBTL1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283488-A1 | HETEROCYCLES USEFUL AS IDO AND TDO INHIBITORS | Hangzhou Innogate Pharma Co., Ltd. (CN) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016165613-A1 | HETEROCYCLES USEFUL AS IDO AND TDO INHIBITORS | HANGZHOU INNOGATE PHARMA CO., LTD. (CN) | 2016-10-20 | — | — | WO | disclosed |