Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11555850 | 0.80 | MAPT (0.61) | MAPTLMNAMAPK1TDP1KDM4E | |
| SCHEMBL24994429 | 0.78 | ALDH1A1 (0.62) | MAPTLMNAACHEKDM4EL3MBTL1 | |
| SCHEMBL18155146 | 0.78 | MAPT (0.58) | MAPTLMNAMAPK1TDP1KDM4E | |
| SCHEMBL28867034 | 0.77 | MAPT (0.60) | MAPTLMNAMAPK1TDP1KDM4E | |
| SCHEMBL20602877 | 0.74 | ALDH1A1 (0.54) | MAPTLMNAMAPK1TDP1KDM4E | |
| SCHEMBL9162336 | 0.74 | ALDH1A1 (0.83) | ACHEKDM4EL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2711990 | 0.74 | MAPT (0.77) | MAPTLMNAMAPK1TDP1KDM4E | |
| SCHEMBL7800482 | 0.74 | GAA (0.72) | MAPTLMNAMAPK1TDP1KDM4E | |
| SCHEMBL690222 | 0.72 | MAPT (0.63) | MAPTLMNAMAPK1TDP1KDM4E | |
| SCHEMBL2712983 | 0.72 | MAPT (0.63) | MAPTLMNAMAPK1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4699908-A | Alkyl substituted pyridazinones and pharmaceutical compositions | CIBA-GEIGY CORPORATION (US) | 1987-10-13 | — | — | US | disclosed |
| US-4629789-A | Alkyl substituted pyridazinones and pharmaceutical compositions | CIBA-GEIGY CORPORATION (US) | 1986-12-16 | — | — | US | disclosed |
| EP-0180542-A2 | Alkyl substituted pyridazinones, processes for producing them, pharmaceutical preparations containing these compounds, and the use thereof | CIBA-GEIGY AG (CH) | 1986-05-07 | — | — | EP | disclosed |