Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 19/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | F10 | P00742 | 3/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.53 |
| ▸ | F12 | P00748 | 1/20 | 0.50 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17236202 | 0.85 | F2 (1.00) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL17222056 | 0.84 | F2 (0.72) | F2ALDH1A1F10PRSS1PRSS2 | |
| SCHEMBL17222054 | 0.84 | F2 (0.72) | F2ALDH1A1F10PRSS1PRSS2 | |
| SCHEMBL17231945 | 0.83 | F2 (0.76) | F2ALDH1A1F10PRSS1PRSS2 | |
| SCHEMBL6921485 | 0.82 | ALDH1A1 (0.63) | F2ALDH1A1F10PRSS1PRSS2 | |
| SCHEMBL6923431 | 0.82 | F2 (0.79) | F2ALDH1A1F10PRSS1PRSS2 | |
| Trifluoroacetic Acid SCHEMBL17221980 | 0.82 | F2 (0.88) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL23997702 | 0.82 | F2 (0.76) | F2ALDH1A1F10PRSS1PRSS2 | |
| SCHEMBL6929087 | 0.81 | F2 (0.75) | F2ALDH1A1F10PRSS1PRSS2 | |
| SCHEMBL6920128 | 0.81 | ALDH1A1 (0.64) | F2ALDH1A1F10PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922535-B1 | THROMBIN INHIBITORS | MERCK SHARP & DOHME (US) | 2021-11-10 | — | — | EP | disclosed |
| US-9469608-B2 | Thrombin inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-10-18 | — | — | US | disclosed |