Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15447644 | 0.84 | ELANE (0.37) | KDM4EALDH1A1GLAGAAMAPT | |
| SCHEMBL15447645 | 0.84 | ELANE (0.42) | KDM4EALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL14699276 | 0.83 | ELANE (0.44) | MAPTTSHRELANE | |
| SCHEMBL2144581 | 0.80 | ELANE (0.53) | ALDH1A1MAPTRAB9AELANE | |
| SCHEMBL14158206 | 0.80 | ELANE (0.50) | KDM4EALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL1636360 | 0.79 | DGAT1 (0.46) | MAOBALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL15447643 | 0.79 | DGAT1 (0.40) | MAPT | |
| SCHEMBL22532250 | 0.78 | DGAT1 (0.35) | ALDH1A1MAPTL3MBTL1KMT2AELANE | |
| SCHEMBL1965693 | 0.77 | DGAT1 (0.42) | KDM4EALDH1A1HPGDMAPTRAB9A | |
| SCHEMBL16532624 | 0.77 | ELANE (0.52) | MAPTTSHRL3MBTL1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2885285-B1 | PYRAZOLE DRIVATIVES WHICH INHIBIT LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INT (DE) | 2016-10-19 | — | — | EP | disclosed |