SCHEMBL18155590

SCHEMBL18155590

CCCN1CC(C)N(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)CC1C

nearest known ligand 0.89

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRKCB P05771 20/20 0.89
PAK4 O96013 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29637733 1.00 PRKCB (0.89) PRKCBPAK4
SCHEMBL597432 1.00 PRKCB (0.89) PRKCBPAK4
SCHEMBL596973 1.00 PRKCB (0.89) PRKCBPAK4
SCHEMBL597422 0.96 PRKCB (0.88) PRKCBPAK4
SCHEMBL23140459 0.94 PRKCB (1.00) PRKCBPAK4
SCHEMBL597574 0.94 PRKCB (1.00) PRKCBPAK4
SCHEMBL29637732 0.94 PRKCB (1.00) PRKCBPAK4
SCHEMBL14038491 0.94 PRKCB (1.00) PRKCBPAK4
SCHEMBL597992 0.94 PRKCB (1.00) PRKCBPAK4
SCHEMBL10076801 0.93 PRKCB (1.00) PRKCBPAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2195321-B1 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES AS INHIBITORS OF PROTEIN KINASE C PFIZER (US) 2016-10-19 EP disclosed