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PRKCB

Protein kinase C beta type · P05771 · PRKCB on Sugi Atlas →

70,043 patent compounds predicted against PRKCB, 50,261 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Balanol Balanol (SCHEMBL62128) 1.00 20/20
Balanol Balanol (SCHEMBL62129) 1.00 20/20
Staurosporine Staurosporine (SCHEMBL8156) 1.00 9/20
Staurosporine Staurosporine (SCHEMBL8157) 1.00 9/20
SCHEMBL117745 SCHEMBL117745 0.56 7/20
SCHEMBL115053 SCHEMBL115053 0.56 6/20
Fasudil Fasudil (SCHEMBL4674) 1.00 5/20
Phorbol Myristate Acetate Phorbol Myristate Acetate (SCHEMBL115567) 1.00 5/20
SCHEMBL162855 SCHEMBL162855 1.00 5/20
Uprosertib Uprosertib (SCHEMBL168584) 1.00 5/20
SCHEMBL190590 SCHEMBL190590 1.00 5/20
SCHEMBL9306 SCHEMBL9306 0.89 5/20
SCHEMBL190415 SCHEMBL190415 0.63 5/20
SCHEMBL78989 SCHEMBL78989 0.62 5/20
Phorbol Phorbol (SCHEMBL72895) 0.62 5/20
SCHEMBL190414 SCHEMBL190414 0.62 5/20
SCHEMBL123495 SCHEMBL123495 1.00 4/20
SCHEMBL123496 SCHEMBL123496 1.00 4/20
SCHEMBL9305 SCHEMBL9305 0.74 4/20
SCHEMBL82376 SCHEMBL82376 0.63 4/20

Clinical trials — most relevant to PRKCB by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity PHASE4COMPLETED
Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients PHASE3ACTIVE_NOT_RECRUITING
Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients PHASE3COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate PHASE2/PHASE3WITHDRAWN
A Phase Ib Study of the Selective PKC-β Inhibitor MS-553 in Patients With Refractory or Relapsed CLL/SLL PHASE1/PHASE2NOT_YET_RECRUITING
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients PHASE1/PHASE2WITHDRAWN
PKC412 and 5-Azacytidine PHASE1/PHASE2COMPLETED
Metformin and Simvastatin Use in Bladder Cancer PHASE2UNKNOWN
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old PHASE2ACTIVE_NOT_RECRUITING
Efficacy of Amlexanox vs. Placebo in Type 2 Diabetic Patients PHASE2COMPLETED
I/II Phase Study Evaluating M1774 in Combination With Fulvestrant in HR+ and HER2- Advanced Breast Cancers PHASE1/PHASE2NOT_YET_RECRUITING
Sirolimus and Gold Sodium Thiomalate in Treating Patients With Advanced Squamous Non-Small Cell Lung Cancer PHASE1WITHDRAWN
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer EARLY_PHASE1COMPLETED
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases. nanNOT_YET_RECRUITING
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Free Fatty Acid Induced Insulin Resistance nanCOMPLETED
Duality of Lipids: the Athlete's Paradox nanCOMPLETED
Ischemic Preconditioning to Prevent Acute Kidney Injury nanCOMPLETED
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome nanCOMPLETED
p-AKT Expression on Clinical Outcomes in Malignant Lymphoma nanCOMPLETED
Fat Induced Insulin Resistance and Atherosclerosis nanCOMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH nanCOMPLETED
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction nanCOMPLETED
Novel Inhibitors of Lipolysis in the Treatment of Lipid a Glucose Metabolism in Obstructive Sleep Apnea Syndrome nanUNKNOWN
Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas nanNOT_YET_RECRUITING
The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder. nanCOMPLETED
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a PRKCB binder may also engage these)

ProteinNameSimilarity
P10102 — 1.000 P10102 →
P05696 — 1.000 P05696 →
P68403 — 1.000 P68403 →
P04409 — 1.000 P04409 →
PRKCA Protein kinase C alpha type 1.000 landscape →
A8KBH6 — 1.000 A8KBH6 →
P68404 — 1.000 P68404 →
Q16974 — 1.000 Q16974 →
P05772 — 1.000 P05772 →
P20444 — 1.000 P20444 →
P05126 — 1.000 P05126 →
P90980 — 1.000 P90980 →
Q7LZQ8 — 0.997 Q7LZQ8 →
Q7SY24 — 0.996 Q7SY24 →
P34885 — 0.995 P34885 →
P05130 — 0.994 P05130 →
Q25378 — 0.994 Q25378 →
P63319 — 0.993 P63319 →
P63318 — 0.993 P63318 →
Q4R4U2 — 0.992 Q4R4U2 →
P09216 — 0.992 P09216 →
P10830 — 0.992 P10830 →
P13678 — 0.992 P13678 →
PRKCG Protein kinase C gamma type 0.991 landscape →
P16054 — 0.991 P16054 →
Q16975 — 0.991 Q16975 →
P05128 — 0.989 P05128 →
PRKCD Protein kinase C delta type 0.988 landscape →
Q64617 — 0.988 Q64617 →
P13677 — 0.987 P13677 →