SCHEMBL18155592

SCHEMBL18155592

CC1c2[nH]nc(NC(=O)c3ccc4ccccc4n3)c2CN1C(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1

nearest known ligand 0.75

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PRKCB P05771 20/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6377459 0.86 PRKCB (0.83) PRKCB
SCHEMBL6374992 0.86 PRKCB (0.76) PRKCB
SCHEMBL598508 0.85 PRKCB (1.00) PRKCB
SCHEMBL6377462 0.85 PRKCB (0.99) PRKCB
SCHEMBL6375622 0.84 PRKCB (0.74) PRKCB
SCHEMBL6377066 0.83 PRKCB (0.89) PRKCB
SCHEMBL6375080 0.83 PRKCB (0.75) PRKCB
SCHEMBL6376847 0.82 PRKCB (0.75) PRKCB
SCHEMBL10076798 0.80 PRKCB (0.81) PRKCB
SCHEMBL596954 0.79 PRKCB (1.00) PRKCB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2195321-B1 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES AS INHIBITORS OF PROTEIN KINASE C PFIZER (US) 2016-10-19 EP disclosed