Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 9/20 | 0.49 |
| ▸ | PARP1 | P09874 | 7/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | EED | O75530 | 1/20 | 0.40 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.40 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.40 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.40 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16625284 | 0.81 | TNKS (0.62) | TNKSPARP1PARP2 | |
| SCHEMBL16625203 | 0.81 | TNKS (0.53) | TNKSPARP1PARP2 | |
| SCHEMBL16625112 | 0.80 | TNKS (0.69) | TNKSPARP1GPR119 | |
| SCHEMBL16625281 | 0.80 | TNKS (0.56) | TNKSPARP1PARP2GPR119 | |
| SCHEMBL16625333 | 0.79 | USP30 (0.63) | TNKSPARP1GPR119USP30 | |
| SCHEMBL16625131 | 0.77 | TNKS (0.65) | TNKSPARP1GPR119 | |
| SCHEMBL16625212 | 0.77 | TNKS (0.61) | TNKSPARP1PARP2 | |
| SCHEMBL16625093 | 0.77 | TNKS (0.52) | TNKSPARP1GPR119 | |
| SCHEMBL20794854 | 0.77 | GPR119 (0.52) | GPR119USP30 | |
| SCHEMBL16617127 | 0.77 | USP30 (0.55) | TNKSPARP1GPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822656-B1 | 3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE | CANCER RES INST ROYAL (GB) | 2016-10-19 | — | — | EP | disclosed |