Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 19/20 | 0.48 |
| ▸ | PARP1 | P09874 | 12/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 9/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16625264 | 0.90 | TNKS (0.49) | TNKSPARP1TNKS2PARP2PARP3 | |
| SCHEMBL16625234 | 0.83 | TNKS (0.52) | TNKSPARP1TNKS2PARP2PARP3 | |
| SCHEMBL16625261 | 0.80 | TNKS (0.57) | TNKSPARP1TNKS2KCNH2 | |
| SCHEMBL16625262 | 0.79 | TNKS (0.49) | TNKSPARP1TNKS2KCNH2 | |
| SCHEMBL16625263 | 0.77 | TNKS (0.50) | TNKSPARP1TNKS2 | |
| SCHEMBL16616942 | 0.76 | TNKS (0.72) | TNKSPARP1TNKS2KCNH2 | |
| SCHEMBL16625250 | 0.72 | TNKS (0.52) | TNKSPARP1 | |
| SCHEMBL18156472 | 0.71 | TNKS (0.53) | TNKSPARP1TNKS2PARP2 | |
| SCHEMBL16625238 | 0.70 | TNKS (0.74) | TNKSPARP1TNKS2 | |
| SCHEMBL16625248 | 0.69 | TNKS (0.54) | TNKSPARP1TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822656-B1 | 3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE | CANCER RES INST ROYAL (GB) | 2016-10-19 | — | — | EP | disclosed |