SCHEMBL18158913

COCCO[C@H]1C[C@@H](COP(=O)(S)O[C@@H]2C[C@H](n3cnc4c(=O)[nH]c(N)nc43)O[C@@H]2COP(=O)(O)S)O[C@H]1n1cc(C)c(N)nc1=O

nearest known ligand 0.50

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	F2	P00734	4/20	0.50

▸	POLB	P06746	1/20	0.47

▸	FUT5	Q11128	1/20	0.43

▸	P2RY2	P41231	1/20	0.43

▸	P2RY4	P51582	1/20	0.43

▸	P2RY6	Q15077	1/20	0.43

▸	TERT	O14746	1/20	0.42

▸	NT5E	P21589	1/20	0.42

▸	P2RY1	P47900	1/20	0.42

▸	TGM2	P21980	1/20	0.40

▸	DTYMK	P23919	2/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL18158918	0.94	F2 (0.50)	F2POLBFUT5P2RY2P2RY4
SCHEMBL16221824	0.88	POLB (0.50)	F2POLBFUT5P2RY2P2RY4
SCHEMBL18158912	0.88	POLB (0.50)	F2POLBFUT5P2RY2P2RY4
SCHEMBL17122137	0.86	F2 (0.47)	F2POLBFUT5TERTDTYMK
SCHEMBL17122127	0.86	F2 (0.53)	F2POLBFUT5P2RY2P2RY4
SCHEMBL18158914	0.85	F2 (0.48)	F2POLBFUT5P2RY2P2RY4
SCHEMBL27103995	0.85	F2 (0.46)	F2POLBFUT5P2RY2P2RY4
SCHEMBL19677793	0.85	F2 (0.46)	F2POLBFUT5P2RY2P2RY4
SCHEMBL19677799	0.85	F2 (0.46)	F2POLBFUT5P2RY2P2RY4
SCHEMBL18158965	0.85	NT5E (0.51)	POLBFUT5NT5ETGM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2016168592-A2	COMPOSITIONS FOR MODULATING C9ORF72 EXPRESSION	IONIS PHARMACEUTICALS, INC. (US)	2016-10-20	—	—	WO	disclosed