SCHEMBL18158912

Cc1cn([C@@H]2CC[C@@H](COP(=O)(S)O[C@@H]3C[C@H](n4cnc5c(=O)[nH]c(N)nc54)O[C@@H]3COP(=O)(O)S)O2)c(=O)nc1N

nearest known ligand 0.50

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	POLB	P06746	1/20	0.50

▸	F2	P00734	2/20	0.47

▸	TERT	O14746	1/20	0.45

▸	FUT5	Q11128	1/20	0.44

▸	P2RY1	P47900	1/20	0.44

▸	P2RY2	P41231	1/20	0.44

▸	P2RY4	P51582	1/20	0.44

▸	P2RY6	Q15077	1/20	0.44

▸	NT5E	P21589	1/20	0.42

▸	TGM2	P21980	1/20	0.40

▸	KRAS	P01116	2/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL16221824	1.00	POLB (0.50)	POLBF2TERTFUT5P2RY1
SCHEMBL16217855	0.96	TERT (0.50)	POLBF2TERTFUT5P2RY1
SCHEMBL16221825	0.93	POLB (0.56)	POLBF2FUT5P2RY1P2RY2
SCHEMBL16221826	0.92	F2 (0.55)	POLBF2TERTFUT5P2RY1
SCHEMBL22434567	0.89	POLB (0.51)	POLBF2TERTP2RY1P2RY2
SCHEMBL16221597	0.89	POLB (0.51)	POLBF2TERTP2RY1P2RY2
SCHEMBL20326935	0.89	POLB (0.51)	POLBF2TERTP2RY1P2RY2
SCHEMBL24239526	0.89	TERT (0.57)	POLBF2TERTP2RY2P2RY4
SCHEMBL16410980	0.89	POLB (0.47)	POLBP2RY1
SCHEMBL17231124	0.88	TK1 (0.39)	POLBP2RY1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2016168592-A2	COMPOSITIONS FOR MODULATING C9ORF72 EXPRESSION	IONIS PHARMACEUTICALS, INC. (US)	2016-10-20	—	—	WO	disclosed