Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.52 |
| ▸ | CKS1B | P61024 | 2/20 | 0.48 |
| ▸ | SKP1 | P63208 | 2/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18163277 | 0.81 | MAP4K4 (0.54) | MAP4K4PRMT5CKS1BSKP1SKP2 | |
| SCHEMBL18163251 | 0.81 | PRMT5 (0.58) | MAP4K4PRMT5CKS1BSKP1SKP2 | |
| SCHEMBL18163226 | 0.79 | PRMT5 (0.56) | MAP4K4PRMT5CKS1BSKP1SKP2 | |
| SCHEMBL16249702 | 0.78 | MAP4K4 (0.55) | MAP4K4PRMT5CKS1BSKP1SKP2 | |
| SCHEMBL461584 | 0.77 | CKS1B (0.62) | MAP4K4CKS1BSKP1SKP2GPR119 | |
| SCHEMBL18163292 | 0.77 | PDE3B (0.52) | MAP4K4PRMT5CKS1BSKP1SKP2 | |
| SCHEMBL6485481 | 0.76 | MAP4K4 (0.53) | MAP4K4PRMT5CKS1BSKP1SKP2 | |
| SCHEMBL19873362 | 0.76 | PARP1 (0.33) | PRMT5ALDH1A1PARP1 | |
| SCHEMBL6477715 | 0.76 | PRMT5 (0.69) | MAP4K4PRMT5CKS1BSKP1SKP2 | |
| SCHEMBL23625711 | 0.75 | MAP4K4 (0.61) | MAP4K4PRMT5CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016165655-A1 | HETEROCYCLIC-IMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海汇伦生命科技有限公司 | 2016-10-20 | — | — | WO | disclosed |