Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18163222 | 0.76 | MAP4K4 (0.52) | PARP1PRMT5ALDH1A1 | |
| SCHEMBL4500297 | 0.75 | HTR3E (0.47) | PARP1PRMT5KDM4EALDH1A1CYP3A4 | |
| SCHEMBL19579757 | 0.65 | KDM4E (0.43) | KDM4EALDH1A1 | |
| SCHEMBL9184856 | 0.62 | — | — | |
| SCHEMBL271615 | 0.60 | — | — | |
| SCHEMBL28844421 | 0.60 | — | — | |
| SCHEMBL18163251 | 0.59 | PRMT5 (0.58) | PARP1PRMT5ALDH1A1DGAT2 | |
| SCHEMBL9023984 | 0.58 | AKR1C3 (0.48) | TRPV1ALDH1A1CYP3A4 | |
| SCHEMBL1187778 | 0.57 | CYP3A4 (0.36) | KDM4EALDH1A1CYP3A4 | |
| SCHEMBL28935546 | 0.57 | JAK3 (0.47) | KDM4EALDH1A1CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3284743-A1 | HETEROCYCLIC-IMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Huilun Life Science & Technology Co., Ltd (CN) | 2018-02-21 | — | — | EP | disclosed |