Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 1.00 |
| ▸ | TUBB3 | Q13509 | 7/20 | 1.00 |
| ▸ | TUBB4A | P04350 | 3/20 | 1.00 |
| ▸ | TUBB | P07437 | 3/20 | 1.00 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 1.00 |
| ▸ | TUBA1B | P68363 | 3/20 | 1.00 |
| ▸ | TUBA4A | P68366 | 3/20 | 1.00 |
| ▸ | TUBB4B | P68371 | 3/20 | 1.00 |
| ▸ | TUBB2A | Q13885 | 3/20 | 1.00 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 1.00 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 1.00 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 1.00 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 1.00 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 1.00 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 1.00 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 1.00 |
| ▸ | EGFR | P00533 | 7/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18163697 | 0.81 | KDR (0.68) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| SCHEMBL3121619 | 0.78 | KDR (0.64) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| Verubulin SCHEMBL29379614 | 0.75 | KDR (1.00) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| Verubulin SCHEMBL2232326 | 0.75 | KDR (1.00) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| Verubulin SCHEMBL29505369 | 0.74 | KDR (0.97) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| Verubulin SCHEMBL2395194 | 0.74 | KDR (0.97) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| SCHEMBL2258430 | 0.73 | KDR (0.71) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| SCHEMBL18552090 | 0.73 | KDR (0.71) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| SCHEMBL18552323 | 0.73 | KDR (0.71) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| SCHEMBL18160921 | 0.73 | KDR (0.60) | KDRTUBB3TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11111252-B2 | Pyrimidine compounds and pyrimido indole compounds and methods of use | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-09-07 | — | — | US | disclosed |
| US-11078214-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-08-03 | — | — | US | disclosed |
| US-11001595-B2 | Pyrimidine compounds and pyrimido indole compounds and methods of use | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-05-11 | — | — | US | disclosed |
| US-20200369681-A1 | PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2020-11-26 | — | — | US | disclosed |
| US-20200369680-A1 | PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-11-26 | — | — | US | disclosed |
| US-10774090-B2 | Pyrimidine compounds and pyrimido indole compounds and methods of use | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2020-09-15 | — | — | US | disclosed |
| US-10457688-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2019-10-29 | — | — | US | disclosed |
| US-20190233432-A1 | PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-08-01 | — | — | US | disclosed |
| US-10233194-B2 | Pyrimidine compounds and pyrimido indole compounds and methods of use | Duquesne Unversity of the Holy Spirit (US) | 2019-03-19 | — | — | US | disclosed |
| US-9994586-B2 | Monocyclic, thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-06-12 | — | — | US | disclosed |
| US-20170253612-A1 | PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2017-09-07 | — | — | US | disclosed |
| US-9688690-B2 | Pyrimidine compounds and pyrimido indole compounds and methods of use | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2017-06-27 | — | — | US | disclosed |
| WO-2017031176-A1 | MONOCYCLIC, THIENO, PYRIDO, AND PYRROLO PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE OF THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2017-02-23 | — | — | WO | disclosed |
| US-20170050978-A1 | Monocyclic, Thieno, Pyrido, and Pyrrolo Pyrimidine Compounds and Methods of Use and Manufacture of the Same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2017-02-23 | — | — | US | disclosed |
| WO-2016168637-A2 | CYCLOPENTA[D]PYRIMIDINES AND SUBSTITUTED CYCLOPENTA[D]PYRIMIDINES AS ANTITUBULIN AND MICROTUBULE TARGETING AGENTS, MONOCYCLIC PYRIMIDINES AS TUBULIN INHIBITORS, AND PYRROLOPYRIMIDINES AS TARGETED ANTIFOLATES AND TUBULIN AND MULTIPLE RECEPTOR TYROSINE KINASE INHIBITION AND ANTITUMOR AGENTS | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2016-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200369680-A1 | PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE | DPYD, HPRT1, TPMT | KDR 3566/4885TUBB3 2627/4885TUBB4A 2737/4885 |
| US-10233194-B2 | Pyrimidine compounds and pyrimido indole compounds and methods of use | DPYD, HPRT1, TPMT | KDR 3538/4885TUBB3 2709/4885TUBB4A 2946/4885 |
| US-20200369681-A1 | PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE | DPYD, TYMP, TPMT | KDR 3751/4885TUBB3 1979/4885TUBB4A 1890/4885 |
| US-20190233432-A1 | PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE | DPYD, HPRT1, TPMT | KDR 3471/4885TUBB3 2792/4885TUBB4A 2864/4885 |
| US-20170253612-A1 | PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE | DPYD, HPRT1, TPMT | KDR 3538/4885TUBB3 2709/4885TUBB4A 2946/4885 |
| US-10774090-B2 | Pyrimidine compounds and pyrimido indole compounds and methods of use | DPYD, HPRT1, TPMT | KDR 3471/4885TUBB3 2792/4885TUBB4A 2864/4885 |
| US-11078214-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DPYD, TYMS, THPO | KDR 2597/4885TUBB3 2345/4885TUBB4A 1473/4885 |
| US-11111252-B2 | Pyrimidine compounds and pyrimido indole compounds and methods of use | DPYD, TYMP, TPMT | KDR 3751/4885TUBB3 1979/4885TUBB4A 1890/4885 |
| US-10457688-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DPYD, TPX2, TYMS | KDR 3311/4885TUBB3 2754/4885TUBB4A 2059/4885 |
| US-20170050978-A1 | Monocyclic, Thieno, Pyrido, and Pyrrolo Pyrimidine Compounds and Methods of Use and Manufacture of the Same | CYP4F3, TYMS, DPYD | KDR 1696/4885TUBB3 1209/4885TUBB4A 2037/4885 |
| US-11001595-B2 | Pyrimidine compounds and pyrimido indole compounds and methods of use | DPYD, HPRT1, TPMT | KDR 3566/4885TUBB3 2627/4885TUBB4A 2737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.