Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.64 |
| ▸ | TUBB3 | Q13509 | 7/20 | 0.64 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.64 |
| ▸ | TUBB | P07437 | 2/20 | 0.64 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.64 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.64 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.64 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.64 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.64 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.64 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.64 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.64 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.64 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.64 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.64 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.60 |
| ▸ | EGFR | P00533 | 5/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19033044 | 0.83 | KDR (0.44) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| SCHEMBL18540797 | 0.82 | KDR (0.44) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| SCHEMBL17528583 | 0.82 | KDR (0.48) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| SCHEMBL18540793 | 0.81 | KDR (0.60) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| SCHEMBL18540800 | 0.78 | KDR (0.67) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| SCHEMBL18163699 | 0.78 | KDR (1.00) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| SCHEMBL23732583 | 0.77 | KDR (0.53) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| SCHEMBL18551759 | 0.77 | TUBB3 (0.56) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| Verubulin SCHEMBL29379614 | 0.75 | KDR (1.00) | KDRTUBB3TUBB4ATUBBTUBA3C | |
| Verubulin SCHEMBL2232326 | 0.75 | KDR (1.00) | KDRTUBB3TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840539-B2 | Substituted pyrrolo,-furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2023-12-12 | — | — | US | disclosed |
| US-11840539-B2 | Substituted pyrrolo,-furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2023-12-12 | — | — | US | disclosed |
| US-11840539-B2 | Substituted pyrrolo,-furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2023-12-12 | — | — | US | disclosed |
| US-11111252-B2 | Pyrimidine compounds and pyrimido indole compounds and methods of use | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-09-07 | — | — | US | disclosed |
| US-11078214-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-08-03 | — | — | US | disclosed |
| US-11078214-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-08-03 | — | — | US | disclosed |
| US-20210155633-A1 | Substituted Pyrrolo,-Furano, and Cyclopentylpyrimidines Having Antimitotic and/or Antitumor Activity and Methods of Use Thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2021-05-27 | — | — | US | disclosed |
| US-20210155633-A1 | Substituted Pyrrolo,-Furano, and Cyclopentylpyrimidines Having Antimitotic and/or Antitumor Activity and Methods of Use Thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2021-05-27 | — | — | US | disclosed |
| US-11001595-B2 | Pyrimidine compounds and pyrimido indole compounds and methods of use | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-05-11 | — | — | US | disclosed |
| US-10947246-B2 | Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-03-16 | — | — | US | disclosed |
| US-20150105407-A1 | Substituted Pyrrolo, -Furano, and Cyclopentylpyrimidines Having Antimitotic and/or Antitumor Activity and Methods of Use Thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2015-04-16 | — | — | US | disclosed |
| US-8946239-B2 | Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2015-02-03 | — | — | US | disclosed |
| US-8946239-B2 | Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2015-02-03 | — | — | US | disclosed |
| US-8946239-B2 | Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2015-02-03 | — | — | US | disclosed |
| US-20140303188-A1 | Substituted Cyclopenta Pyrimidine Bicyclic Compounds Having Antitmitotic And/Or Antitumor Activity And Methods Of Use Thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2014-10-09 | — | — | US | disclosed |
| US-20140303188-A1 | Substituted Cyclopenta Pyrimidine Bicyclic Compounds Having Antitmitotic And/Or Antitumor Activity And Methods Of Use Thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2014-10-09 | — | — | US | disclosed |
| US-20140303188-A1 | Substituted Cyclopenta Pyrimidine Bicyclic Compounds Having Antitmitotic And/Or Antitumor Activity And Methods Of Use Thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2014-10-09 | — | — | US | disclosed |
| US-20100010016-A1 | BICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2010-01-14 | — | — | US | disclosed |
| US-20100010016-A1 | BICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2010-01-14 | — | — | US | disclosed |
| US-20100010016-A1 | BICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010016-A1 | BICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF | ABCC1, ABCB1, ABCG2 | KDR 4053/4885TUBB3 140/4885TUBB4A 226/4885 |
| US-11840539-B2 | Substituted pyrrolo,-furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof | ABCB1, ABCC1, ABCG2 | KDR 3949/4885TUBB3 511/4885TUBB4A 350/4885 |
| US-20150105407-A1 | Substituted Pyrrolo, -Furano, and Cyclopentylpyrimidines Having Antimitotic and/or Antitumor Activity and Methods of Use Thereof | ABCB1, ABCC1, ABCB11 | KDR 4008/4885TUBB3 255/4885TUBB4A 331/4885 |
| US-10947246-B2 | Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof | ABCB1, ABCC1, ABCB11 | KDR 4008/4885TUBB3 255/4885TUBB4A 331/4885 |
| US-11078214-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DPYD, TYMS, THPO | KDR 2597/4885TUBB3 2345/4885TUBB4A 1473/4885 |
| US-20210155633-A1 | Substituted Pyrrolo,-Furano, and Cyclopentylpyrimidines Having Antimitotic and/or Antitumor Activity and Methods of Use Thereof | ABCB1, ABCC1, ABCG2 | KDR 3949/4885TUBB3 511/4885TUBB4A 350/4885 |
| US-20140303188-A1 | Substituted Cyclopenta Pyrimidine Bicyclic Compounds Having Antitmitotic And/Or Antitumor Activity And Methods Of Use Thereof | ABCC1, ABCG2, ABCB1 | KDR 4359/4885TUBB3 101/4885TUBB4A 278/4885 |
| US-11111252-B2 | Pyrimidine compounds and pyrimido indole compounds and methods of use | DPYD, TYMP, TPMT | KDR 3751/4885TUBB3 1979/4885TUBB4A 1890/4885 |
| US-11001595-B2 | Pyrimidine compounds and pyrimido indole compounds and methods of use | DPYD, HPRT1, TPMT | KDR 3566/4885TUBB3 2627/4885TUBB4A 2737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.